Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy
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چکیده
منابع مشابه
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.
Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as ...
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The mechanism of action of artemisinin appears to involve two steps. In the first step, activation, intra-parasitic iron catalyses the cleavage of the endoperoxide bridge and the generation of free radicals. In the second step, alkylation, the artemisinin-derived free radical forms covalent bonds with parasite proteins.
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ژورنال
عنوان ژورنال: Microbiological Reviews
سال: 1996
ISSN: 0146-0749
DOI: 10.1128/mr.60.2.301-315.1996